[3] Georqiou P, Tan E, Gouvas N ,et al. Extended lymphadenectomy versus conventional surgery for rectal cancer: a meta-analysis[J]. Lancet Oncol, 2009, 10(11): 1053-1062.

　　[4] Wei C, Pan Q, Wu K, et al. Clinical characterization for proliferation and metastasis in advanced hepatocellular carcinoma patients[J]. Int J Clin Exp Pathol, 2015,8(10):13429-13431.

　　[5] Kirtane AR, Kalscheuer SM, Panyam J. Exploiting nanotechnology to overcome tumor drug resistance: Challenges and opportunities[J]. Adv Drug Deliv Rev, 2013, 65( 13-14) :1731-1747.

　　[6] 郭颖, 赵丽霞, 张林西, 等. 结直肠腺癌中耐药相关因子的表达及意义[J]. 临床与实验病理学杂志,2015, 31(10): 1167 - 1169.

　　[关键词] 结直肠肿瘤;多药耐药;Topo-II;P-gp;Ki-67

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